The affected woman with such a rare autoimmune disease ended up with resolved bloody nasal discharge and crusting after six-month treatment, though her nasal deformity remained unchanged. The report notes that the patient will continue receiving the antibody treatment, but it stays unclear if she will reserve surgery to rebuild her collapsed nose.
The New England Journal of Medicine (NEJM) recently releases a report that a facial plastic surgery clinic accepted a 34-year-old female patient whose nasal bridge has completely collapsed and nose tip has retracted. This nose deformity may have emerged over the past 7 years. Also, a series of related symptoms were detected, including persistent inflammation in her nasal cavity and the lining of her sinuses and polyps.
Doctors perform a physical examination indicating her nasal bones almost totally lost or degraded, and a computed tomography (CT) scan showing a large hole formed in her septum. Such severe inflammation turned out to be a result of high levels of antibodies targeting proteinase 3 (PR3). It’s a type of autoantibodies, also known as autoimmune antibodies, meaning her nose deformity might be caused by a rare autoimmune disorder, granulomatosis with polyangiitis…
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